![]() ![]() Materials and Methods The experimental regimen has been described (11). Abstracts of these findings have appeared (12). The present paper describes certain pathologic manifestations of chronic sodium chloride toxicity which were observed in these animals. Recently Meneely, Tucker, and Darby (11) reported on the growth of rats fed for 20 weeks on purified diets containing seven different levels of sodium chloride. A few experiments of a chronic nature have been made using the mouse (7), the albino and the kangaroo rat (8), the dog (9), and the cow (10). Binet, Dejours, and Lacaisse (6) raised rats on a high sodium chloride regimen and described a resulting renal hypertrophy and functional adaptation. This was accomplished by substituting saline solution for drinking water. Sapirstein, Brandt, and Drury (4) and Gross (5) produced hypertension in rats fed diets high in sodium chloride and restricted in the amount of fluid. Mosier (3) studied the adrenal glands in rats on diets very high in sodium chloride. Campbell (2) reported the possibility of kidney damage in the rat fed a diet containing more than 5 per cent of sodium chloride. A search of the literature reveals a number of papers which describe toxic effects of sodium chloride in fowl (1), but a paucity of information relative to mammals. The need for common salt in the diet is an ancient, inveterate cognition, deeply rooted in human mores, to such an extent that little thought has been given to the chronic toxicity of sodium chloride. ![]()
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